Department: Stem cell group
University: Genome Institute of Singapore
Dr Tong Ming Liu obtained his PhD in genetics from Institute of Hydrobiology, Chinese Academy of Sciences in 2002. From 2006, he led an team to study human mesenchymal stem cells (hMSCs), focusing gene therapy and cell therapy for cartilage and bone in hMSCs, including comparison of hMSCs from different source, immortalization of hMSCs, screening and identification of novel genes regulating MSC differentiation or quality, gene manipulation of hMSCs, hMSCs from human pluripotent stem cells, modeling of cartilage and bone diseases via iPS, conversion of human fibroblasts into osteoblasts by defined factors or small molecules etc. He supervised three external grants totaling more than 2.5 millions as co-principal supervisor from 2006. He have published more than 20 paper in international journals with more than 1400 citation, including Nat Cell Biology, PNAS, Stem cells, Arthritis &Rheumam etc.
Bone and cartilage disease modeling, drug screening and gene correction direct differentiation of pluripotent stem cells toward cartilage and bone reprogramming of fibroblasts using defined factors.
Gene therapy for cartilage regeneration and repair in regenerative medicine. Signaling pathway of genes regulating cartilage differentiation of human mesenchymal stem cells. Molecular basis of mesenchymal stem cells maintaining their stemness. Stem cell biology and technique
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