Abdullah M. Iliyasu (aka Abdul M. Elias)Professor
Department of Computational Intelligence & Intelligent Systems
Tokyo Institute of Technology, Japan
April - 2018
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Rising costs of power generation as a result of increased condenser tube scaling and corrosion have become critical areas that need intervention at Eskom’s power stations in South Africa. In the past few years, the quality of cooling and raw water has deteriorated with increased concentrations of scale formation metals such as calcium (Ca) and magnesium (Mg) as well as Natural Organic Matter (NOM). The Dissolved Organic Matter (DOC) fraction of NOM in the water forms complexes with metals Ca and Mg under various conditions. In this study, the Cooling Water (CW) and Raw Water (RW) at Lethabo and Duvha power stations were sampled and were analyzed for metals as well as organics and the data obtained was fitted into a Visual MINTEQ chemical model and Langelier Saturation Index (SI) calculations coupled with calcium carbonate precipitation potential models. The data obtained indicated that as the DOC concentration increased, the SI values decreased which may be attributed to the to complexation of Ca and Mg (the scaling metals) bound to DOC, leaving relatively lower concentrations of the free Ca and Mg ions until the reactive sites of DOC were saturated. The seasonal changes affect pH, DOC and concentrations of other metals present in the water that influenced complex formation and scaling.
Pdf Full text Journal HomeDrug Resistance has been reported for most current therapeutic agents against cancer cells, regardless of whether these are chemotherapeutic agents, target therapy or immunotherapy. Heterogeneity of tumor cells is considered an important factor for drug resistance. This heterogeneity is due to renewable small subpopulations of cells called stem-like cancer cells. It is highly possible that different generations of cells exist within one tumor, thus targeting them would result into alternative outcomes as some clones are sensitive and others are resistant to therapeutic agents. Further, tumor cells also have the capability to evolve over time; adding another challenge to treat cancer [1-3].
Initiation of chemo or target therapy for cancer patients depends on the clinical diagnosis, tumor stage, tumor type, molecular characteristics and gene expression.
Corresponding author: Yahya I. Elshimali, Department of Pathology and Oncology, UCLA School of Medicine & Charles R. Drew, University of Medicine and Science, USA, Tel.: +1-818-515-7618, Fax: +1-818-994-9875, E-mail:elshimali@gmail.com, yahyaelshimali@cdrewu.edu
Pdf Full text Journal HomeThe management of patients with open abdomens is an evolving concept. Certain techniques for managing the open abdomen patients can be effective in treating ACS. The goal of therapy is to maximize tissue perfusion and minimize potential intra abdominal complications, such as fistulas and hernias. Meticulous care of the bowel, minimizing trauma from techniques or systems used to cover abdominal contents and protection of the bowel from exposure to the environment can reduce the complications associated with the open abdomen. A Temporal Abdominal Closure should not only protect the intra abdominal contents, but facilitate primary closure of the fascia and minimize the need for secondary repairs of ventral hernias and subsequent repair. Serial bladder pressure monitoring should be a part of post-operative management protocols in high-risk patients and decompression of the abdomen with a pressure of > 25-30 mmHg should be considered even without clear clinical evidence of ACS. While many closure techniques are reported in the literature, a dynamic closure technique, such as Vacuum pack appears to have an advantage in meeting most requirements for managing an open abdomen. IAH and ACS remain the most significant considerations for the management of the open abdomen. IAH and ACS are in part iatrogenic and can be minimized with the appropriate resuscitation protocols. Complications found in patients with open abdomens may be minimized with Vacuum pack Therapy resulting in early closure of the abdomen.
Pdf Full text Journal HomeMassive degeneration of the basal forebrain cholinergic cells is one of the major histopathological changes of Alzheimer’s disease (AD). The degeneration leads to Acetylcholine (ACh) deficits in the cortex and hippocampus. AD disease severity was negatively correlated with ACh expression. We conducted neuronal transplantation with cells derived from Human Induced Pluripotent Stem (hiPS) cells into the bilateral hippocampi of human amyloid precursor protein transgenic AD mice. The transplantation significantly improved cognitive dysfunction in the mice.
Transplanted neurons differentiated further in the host cortex into human Choline Acetyl Transferase (ChAT)+ cholinergic neurons. In the hippocampus, the grafted cells preferentially differentiated into human vesicular GABA transporter (VGAT)+ cells. We suggest that transplanted neurons may compensate for neurotransmitter loss associated with AD lesions.
Citation: Suzuki N, Shimizu J, Takai K, Arimitsu N, Suzuki T, et al.(2018) Cellular and Molecular Mechanisms Governing Functional Recovery of Dementia Mice after Neuronal cell Transplantation.J Neurosci Neurosurg1:103
Pdf Full text Journal HomeTuberculosis is one of the so-called social diseases; therefore the epidemiological parameters of tuberculosis are often used as an indicator of social well-being in the country [1]. At first glance, the existence of a link between suicide and tuberculosis mortality seems doubtful since suicidal behavior is a psychosocial phenomenon, while tuberculosis is an infectious disease. However, there are at least several possible aspects of such link at the individual level. First, there are arguments in favor of the psychosomatic nature of tuberculosis [2]. Here, the common etiological factor of suicidal behavior and tuberculosis can be psychosocial distress accompanied by a decrease in the immunity, in general, the body’s resistance, which increases the risk of tuberculosis [2]. Besides, an important aspect of existence of relationship between the suicidal behavior and tuberculosis is a suicidal behavior of patients with tuberculosis. One of the most common mental disorders in patients with tuberculosis is depression, which increases the risk of suicide [3]. The literature also reports of an increase in the risk of suicidal behavior against the background of anti-tuberculosis drugs [4].
In general, the mortality rate of tuberculosis patients from external causes: injuries, alcohol poisoning, murders and suicides, is 4 times higher than in the common population [5].
Pdf Full text Journal HomeProtein-Protein Interactions (PPIs) help understanding disease processes and their mechanisms. Ideally, researcher would like to understand the full network of PPIs that take place within a cell “interactome”, that is why Open Reading Frame (ORF) filtering method was utilized. ORF is a DNA fragment that lacks stop codon and has the potential to demonstrate a physiological interaction. ORFs are obtained by random shearing of DNA into small fragments. Fragments are filtered by insertion upstream of a selectable marker, to allow the survival of cells that only have an ORF. As vast majority of out of frame fragments encodes a premature stop codon. Here we present a method for filtering of genic ORFs ‘real gene’ which results in a physiological protein. Furthermore, researchers thought fragments libraries rather than full-length libraries are perhaps counterintuitive, as expected to result in a high rate of false negatives. However, researchers have found fragments libraries rather than full-length reduce number of false negative interactions. Lastly, great advantage to note is while using fragmented library it allows localization of interaction site, offering a robust path for drug targets, treatments towards cancer and the arising resistance to antibiotics.
Citation: Al-Thani NM, Andrews SS, Büsselberg D. Open Reading Frame Filtering Methods for Identification of Genic Sequences. Methods Microbiol Mol Biol. 2018 Jan; 1(1): 105
Pdf Full text Journal HomeThe most common disease entity of the anal area in dogs, Anal Gland Disease (AGD), is directly associated with paired structures located on either side of the anus. Despite frequent manifestations of AGD in both canine and feline populations, veterinarian-client conversations addressing the prevention and management of AGD are typically avoided during routine exam room discussions. Unfortunately, AGD consultations most commonly occur when an animal presents at the clinic with an attendant anal gland problem. Compression of the internal and external muscles of the anal sphincter and the concomitant mechanical pressure of stool during defecation effects a full or partial emptying of anal glands: Problems related to AGD are primarily associated with the inability of the anal glands to empty. Reduction in the incidence of AGD can be accomplished when firm stool exerts enough pressure on the anal glands to allow for natural gland expression, reducing the potential for inflammation. This is especially significant in the management of obese animals and small breeds diagnosed with the disease.
Citation: Ehrenzweig J. Novel Fiber-rich Supplement Effective for Prevention and Treatment of Acute, Episodic and Chronic Anal Gland Disease in Dogs and Cats. Int J Vet Anim Med. 2018 Jan; 1(1):104
Pdf Full text Journal HomeWhile the number of therapeutic biologics on the market has dramatically increased in the past decades, oral delivery of protein/peptide drugs is still one of the challenges for biopharmaceutical scientists. Transferrin (Tf), with its receptor-mediated transcytosis mechanism across intestinal epithelium, has been proven as a potential oral delivery carrier for different protein therapeutics. However, one of the major rate-limiting issues of Tf in oral absorption is that Tf Receptor (TfR) is selectively expressed on the basolateral surface instead of the apical surface of the intestinal epithelium, and thus, limits the mucosal transport capacity of Tf across the intestinal epithelium. To overcome this limitation and develop a more efficient oral delivery carrier, a novel transcytosis mechanism was proposed. The proposed transcytosis mechanism is composed of three major steps: apical binding and endocytosis of Tf with a cationic peptide carrier, intracellular cleavage of the linker between peptide and Tf, and basolateral exocytosis by TfR. The feasibility of the proposed approach was demonstrated when Tf was conjugated to poly-L-lysine (PLL) using a pHsensitive Nitrilo Triacetic Acid (NTA) linker in the presence of nickel (Ni2+). The results of Caco-2 transcytosis assay suggested that the transcytosis rate of histidine-tagged Tf could be unidirectionally increased from apical to basolateral compartment when co-incubated with Ni2+-NTA-PLL.
Pdf Full text Journal HomeMitral stenosis still continuing to be a cause of morbidity and mortality in this part of the country. Restenosis rates after PTMC are 10-20%, and after CMV 20-40% in the coming 2 decades [1]. In REDO PTMC the valve is fibrotic and commmisural morphology which is split in the first procedure becomes fibrotic and calcified. The routine scores which analyze the valve does not take into consideration the commercial morphology so we aimed to study new Echocardiographic parameters and comparison with the existing scores in predicting immediate outcomes of REDO PTMC.
Methods and Results: 42 symptomatic patients with mitral restenosis who have undergone REDO PTMC were enrolled and they were divided into 2 cohorts on the outcome as optimal (n=27) and suboptimal (n=15) groups Mean WILKINS SUTARIA and New REDO score were 7.89, 2.33, 8.96 in optimal group, 8.53, 1.60, 10.20 in suboptimal group with significant p value of 0.007 for new REDO score predicting its superior sensitivity over other 2 scores.
Pdf Full text Journal Home
Boffin access limited is an emerging Open Access publisher with nearly forty journals spanning several fields of Science, Technology, Engineering and Mathematics (STEM). Our aim is to create an international venue for researchers from all walks of life to share and exchange their findings in order to push the boundaries of current knowledge.
read moreOn behalf myself, our erudite editorial board members, and the hardworking staff of Boffin Access Limited, it is my pleasure to invite you to share your recent work with the wide readership of the Imaging and Reports Journal (IRJ). Although new, the IRJ is determined to emerge as a respectable repository for research to shape future technologies in and related to medical imaging, radiology, imaging science, etc.
Our editorial board is a diverse and intellectual team comprising of scholars from divergent academic and geographic backgrounds, whose experience will guide policy and provide direction for the young journal. Similarly, we have assembled a pool of knowledgeable, energetic, and dedicated reviewers who will help to enrich the quality of every submission made to the journal.
At IRJ, for authors, we promise professional and timely handling and turnaround of reviews (within weeks), publication of accepted manuscripts online within days as well as provide high visibility and impact for all published articles. For reviewers, we value your immense contributions to the peer review process and we undertake to show this appreciation via numerous tailor-made incentives. For our esteemed readers, we pledge to provide you with an open-access platform to digest contents of original articles, reviews, communications, etc. within the multi-disciplinary scope of the journal (see here)
I am pleased to invite all those interested in the pursuit and dissemination of
knowledge to associate with IRJ in any capacity.
Submissions are now open and we look forward to receiving your valuable
contributions
Department of Computational Intelligence & Intelligent Systems
Tokyo Institute of Technology, Japan
I am working as an Editor-in-Chief for “Drug Design Development and Delivery Journal. DDDD”. This is an Open access, peer reviewed journal who publishes scholarly peer reviewed articles on the most important aspects drug, delivery and development
For information on journal’s Aims and Scope, please visit: click here
The journal is dedicated to publishing high-quality content by which it will pave new platform to exchange and update the current knowledge. Our Committed editors and editorial staff communicate latest updates through various platforms like blogs, social media networking, and websites among scientific communities. Boffin Access Limited adopted internationally accepted peer review process and ethical policies in publication, therefore, our editors, reviewers, and authors could make independent decisions and promote our brand value.
As an emerging open access publisher we welcome researchers from various parts of the globe and join us to support to improve the quality of our services. We are delighted to work with you and believe your expertise and experience will be an added advantage.
The journal Boffin Access Limited journal, Drug Design Development, and Delivery Journal is one such kind of source which provides new age developments and finds the significant gaps in drug development and delivery processes.
Department of Physics and Nuclear Medicine
New York City University, USA
The Systems and Computational Biology Journal invites you to submit an article for the upcoming issue. Article types include original research, reviews, case reports, communications, and editorials/letters. The Systems and Computational Biology Journal is an open access peer reviewed journal that endeavors to report the most recent developments in systems biology and computational biology. Systems and Computational Biology Journal bridges basic biology and applied biology to provide new insights for understanding complex biological systems to develop new drugs, targets, and methods to identify and treat various diseases. The Systems and Computational Biology Journal strives to publish high quality content and to follow internationally accepted review and editorial policies and appreciates the efforts of individuals who wish to submit novel and unpublished data for publication.
Potential Topics for Submission to the Systems and Computational Biology Journal:
• Computational Pharmacology • Computer-Aided Drug Design • Chemical-biology-specific modeling, and structural biology • Interfollicular epidermal progenitor cell proliferation • Modeling and simulation of cell biological systems • High-performance computational systems biology and parallel implementations • Multi-scale and spatial modeling and analysis methods • Model integration from biological databases • uORF‐dependent translational control of gene expression • Protein Biosynthesis & Quality Control • Cell Adhesion, Polarity & Cytoskeleton • Novel Approaches to Bioinformatics Problems in Drug Design • Protein-Protein Interactions: 2 Hybrid & 3 Hybrid Systems • Mass spectrometry and protein profiling • Biomarkers and Diagnostics • Top Down & Bottom Up Approaches • Immunoinformatics&itsAplications • Advancements in Sequencing Techniques • Drug design & Drug discovery • Toxicogenomics, Transcriptomics&Transgenomics • Computational biomodeling • Technologies for Protein Analysis • Cancer Computational Biology • Bioimage Analysis • Graphics processing units • Simulation of spatio-temporal dynamics • Molecular docking • Designing and management biological databases • Massively Parallel Signature Sequencing (MPSS)
Please submit your manuscripts at: Place live link here for submissions
Department of Laboratory Medicine and Pathology
Mayo Clinic University, USA
Dear Colleagues,
I recommend you the Journal of Dentistry and Dental Medicine is a great journal. The team is a really kind of me.
I am cordially inviting you to submit your research works to the Journal of Dentistry and Dental Medicine (JDDM). I aim to make JDDM create a platform for worldwide scientists, research scholars to promote our journal and request you to share your ideas and update their knowledge by sharing latest advancements in the related field of Dentistry, Prosthodontics, Endodontics, Forensic Dentistry, History of Dental Medicine and Dentistry, Veterinary Dentistry, Dental materials, Stomatology, Implants, Paediatric dentistry treatments, Dental laser applications.
The policy of the journal is to publish Original papers, Review articles, case reports, advanced and latest techniques in the field of dentistry and dental medicine.
As an Editor-in- chief (Xavier RIAUD DDS, PhD) and Boffin Access Limited would like to invite to submit your manuscripts to Journal of Dentistry and Dental Medicine
Hope to receive a positive response and support towards our journal.
Department of Dental Surgery
National Academy of Dental Surgery, France
As Editor-in-Chief of the Journal of Neuroscience and Neurosurgery, I invite you to submit manuscripts of various types, from research, development, clinical studies to full articles and short communications.
Journal of Neuroscience and Neurosurgery, Clinical Neurophysiology, Epilepsy, Hospice and Palliative Medicine, Neurodevelopmental Disabilities, Neuromuscular Medicine, Neurocritical Care, Vascular Neurology (stroke), Behavioral Neurology , child neurology, headache, multiple sclerosis, neuroimaging, neurorehabilitation, and interventional neurology diagnosis methods, and all related fields.
Neuroscience has a very wide field since we go from the basic sciences to the clinic. I suggest themes concerning neurodegenerative diseases that are dementia but also bipolar disease rich in cognitive disorders. These interfaces are to explore including depression, dementia or depression post-stroke.
This new journal will allow fruitful exchanges between neurologist, psychiatrists, and neurosurgeons; the journal is committed to publishing quickly without neglecting a peer review
Please submit your manuscripts to: Submit Manuscript
Department of Medicine
University of Nantes, France
Dear Colleagues, Professors, Academicians, Scholars, Researchers, and Scientists,
I am writing to invite you to submit your works to International Journal of Biopharmaceutical Sciences (IJBS) (Boffin Access Limited). IJBS is committed to rapidly delivering high–quality research findings and results to the world. We aim to make IJBS top publication in its field and to offer a platform for scientists all over the world to promote, share and discuss various new issues and developments in area of Biopharmaceutical Sciences. IJBS has an editorial policy of publishing original, high scientific quality Reviews, Research Articles, Methods, Techniques and Evaluation Reports in all areas of Biopharmaceutical Sciences. Based on your outstanding scientific contribution to your field, the Editor–in–Chief (Prof. Dr. Alireza Heidari, Ph.D., D.Sc.) and Boffin Access Limited would like to invite you to submit your manuscripts to International Journal of Biopharmaceutical Sciences (IJBS)
I sincerely hope you will accept our invitation to submit your papers International Journal of Biopharmaceutical Sciences (IJBS). Although there are already some good journals in the field, this journal presents some new opportunities.
I am looking forward to hearing from you, with a positive response, I hope!
Please feel free to send me any questions, concerns or comments as well.
Thanks and we really appreciate your contribution.
Department of Chemistry
California South University, USA
International Journal of Veterinary and Animal Medicine (IJVAM) is manifold journal, which includes the major area of research and interest in veterinary medicine. It accepts but not limited to the following thematic areas; clinical medicine and surgery, biotechnology, theriogenology, physiology, pharmacology, pathology, microbiology, immunology, anatomy, biochemistry, parasitology, epidemiology, breeding and genetic, feed and nutrition, wildlife, animal products and their processing and related fields. We invited you to submit your research results, reviews, case studies, policy papers, and related communications dedicate to veterinary and animal medicine.
The distinguished expertize of the editorial board welcomes and encourages your novel contributions to share with the scientific community and the world. Therefore, on behalf of the editorial boards, I cordially invite you to submit your discoveries and communications to IJVAM.
The Guidelines about author instructions and additional information can be found at International Journal of Veterinary and Animal Medicine.
Thanks for your contribution,
Department of Veterinary microbiology and molecular biology
Tuskegee University, USA
We are writing to introduce the International Journal of Surgical Procedures to you. IJSP is a newly launched journal with an open access peer-reviewed journal. The journal publishes original research articles, review articles, case reports, case reviews, editorials and letters focusing on Surgery and Surgical Procedures.
We kindly encourage you to contribute a manuscript in an upcoming issue of International Journal of Surgical Procedures. Based on your expertise, it is a great pleasure for us to invite you to contribute an article in our journal. We are positive this journal will offer you a meaningful scientific venue for your work.
If you are interested or would like further information regarding this journal, kindly follow the link:
click here
We are looking forward to a long lasting scientific relationship.
Thank You.
Best Regards
Department of Surgery
McGill University Health Centre, Canada
Dear Esteemed Colleagues, Dear Friends,
As Chief Editor of the Journal of Clinical Dermatology and Dermatitis (CDD), an Open Access journal from Boffin Access Limited., a fast-growing publishing group which adopted internationally recognized ethical policies in publication, I am fortunate and glad to closely work with distinguished editorial board members and reviewers.
CDD is dedicated to publish in high quality and peer-reviewed articles on the most important aspects of dermatology and skin surgery, and represents a new platform to exchange and update the current knowledge on skin care management.
For more information on journal’s aim and scope, please visit: click here
Please submit your manuscripts to: Submit Manuscript
I cordially invite you, worldwide scientists and clinicians, to submit your best research findings or clinical case studies at your earliest convenience. Your participation is greatly appreciated.
Thanks and Regards,
Department of Pharmaceutical Sciences and Nanobiotechnology
University of California San Diego, USA
I am grateful to invite you to submit your research work in the field of Cancer and Related Clinical Translation to the Journal of Cancer Research and Oncobiology.
The Journal of Cancer Research and Oncobiology is an open access and peer-reviewed bimonthly journal that is devoted to publishing high quality original research papers, reviews, perspectives, rapid communication, short communications, mini reviews and commentaries.
Our professional editorial board members will review the manuscripts submitted by scientists, clinicians, academicians and researchers and make prompt response.
Your participation is greatly appreciated and I believe that you would make an excellent contribution for the advancement in cancer diagnosis, prognosis and treatment.
Looking forward to receiving your submission
Kind Regards
Department of Pathology and Oncology
University of Medicine and Science, USA
We take the privilege to invite you to write a research Article, Review Articles, Case Reports, Short Review, and Short Commentary based on your research interest, which would be published in the upcoming issue of our International Journal of Cardiology and Cardiovascular Medicine (IJCCM). We strongly believe that your potential research would be beneficial to the people working in the fields of Medical&Clinical Research. If possible, I would appreciate receiving your submission on or before Feb-28th- 2018.
Our journal will involve publications related to all areas of Cardiology. With technology in support of clinical practice, the results of major studies and research in cardiology centers around the world, we will certainly have many studies to be published and the IJCCM expects their valuable collaboration.
Thankyou for your time and consideration in this matter.
We look forward to hear from you soon!
For more details about the MCR: click here
Department of Cardiology
University of Sao Paulo, Brazil
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