Designation: Assistant Professor
Department: Medicine & Stem Cell Research (AIMMSCR)
University: Amity University
Dr. Dhruv Kumar completed his Ph.D. in Cellular, Molecular and Industrial Biology from the University of Bologna (UNIBO), Italy under Indo-Italian Government fellowship in 2012. After completion of his Ph.D., he received four and a half years of Postdoctoral training from the University of Kansas Medical Center, Kansas City, USA where he worked on Translational Cancer Research. During his Postdoctoral training, he worked on several cancers, including Prostate, Pancreatic, Breast and Head and Neck Cancer. First two and a half years of his postdoctoral training was focused on understanding the molecular mechanism (s) of the regulation of Autophagy and Apoptosis in Cancer Stem Cells (Prostate, Pancreatic and Breast). Specifically, he studied the molecular mechanism (s) of Rottlerin -induced Autophagy in Cancer Stem Cells (CSCs) via PI3K/Akt/mTOR signaling pathways. Later, Dr. Kumar investigated the molecular cross-talk between the tumor microenvironment (Tumor Associated Fibroblast (TAF)) and Head and Neck Squamous Cell Carcinoma (HNSCC) via HGF/c-MET and bFGF/FGFR signaling pathways. In addition, Dr. Kumar also worked on intra-tumor mutational heterogeneity in Head and Neck Squamous Cell Carcinoma, developed an in vitro model for Radiation-Induced Fibrosis (RIF) in Head and Neck Cancer, molecular mechanism (s) of combination of naturally derived chemo-preventive agents (Curcumin in combination with other anticancer compounds) in Head and Neck Squamous Cell Carcinoma and the characterization of exosomes released from cancer stem cells (CSCs).
His research interest, mainly focuses on Translational Cancer Research, Cancer Stem Cell, Drug Discovery, and Bioinformatics.
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