Drug Design Development and Delivery Journal

Nature: A Rich Source of Potent Therapeutics

Zvi G Loewy

Professor of Touro College of Pharmacy and New York Medical College

Corresponding author

Zvi G Loewy
Professor
Touro College of Pharmacy
New York Medical College
USA
Tel: 646-981-4718
E-mail: zvi.loewy@touro.edu

  • Received Date: March 30, 2018
  • Accepted Date: April 02, 2018
  • Published Date: April 04, 2018

DOI:   10.31021/ddddj.20181102

Article Type:   Editorial

Manuscript ID:   DDDDJ-1-102

Publisher:   Boffin Access Limited.

Volume:   1.1

Journal Type:   Open Access

Copyright:   © 2018 Loewy ZG.
Creative Commons Attribution 4.0


Citation

Loewy ZG. Nature: A Rich Source of Potent Therapeutics Drug Des Dev Deliv J. 2018 April; 1(1):102

Summary

Nature is a rich source of candidate medicinal products. Herbs, plants and microbes have been shown to deliver potential therapeutic remedies for inflammatory disease, complex infections, metabolic indications and neurological disease.

Three herbs Sambucus nigra, Centella asiatica and Echinacea purporea are showing tremendous potential in the treatment of inflammatory and metabolic diseases. The herbs have been shown to elicit promising anti-inflammatory effects in both oral disease as well as diabetes. Sambucus and Echinacea inhibit proinflammatory activities and have demonstrated anti-bacterial activity. Centella increases collagen production and contributes to wound healing. The herbs have been delivered in a variety of formats including oral rinses, transmucosal patches and hydrogels. Positive clinical results have been reported for gingivitis and periodontitis [1] and in the treatment of diabetic foot ulcers [2].

One of the major medical challenges today is combating biofilms that are frequently found on implantable medical devices. Biofilms are complex structures that include diverse microbiota, some of which can be pathogens. The microbes in biofilms are encapsulated within a polysaccharide matrix. Antibiotics for the most part have not been successful in controlling biofilms. Recently, anti-microbial approaches based on “microbial exchange” have shown much promise. Probiotics that have been used to treat gastrointestinal disorders may have significantly broader healthcare applications. Reports have demonstrated the potential for probiotics in oral health [3], cancer and cardiovascular disease [4]. Cannabis has been used by many societies and cultures over time providing both recreational as well medicinal properties. Three subspecies of cannabis have been characterized including cannabis sativa, cannabis indica, and cannabis ruderalis. The phytochemical components of cannabis are numerous, and include more than 400 naturally occurring compounds and greater than 100 different cannabinoids [5]. The five main cannabinoids including cannabidiol, cannabichromene, cannabigerol, Δ 9-tetrahydrocannabinol and cannabinol demonstrate strong antimicrobial activity [6]

Intensive biomedical research has focused on identifying potential applications of cannabinoids. The development of a specialized medical cannabis has resulted in a cannabis rich in cannabidiol (CBD) and low in Δ 9-tetrahydrocannabinol (THC). Clinical application areas being pursued include seizures, anti-convulsive therapy, chronic pain, spasticity associated with multiple sclerosis, post-traumatic stress disorder treatment, memory loss-Alzheimer’s disease and cancer tumor growth [7]. With the innovative advances in molecular biology and genomics, therapeutic applications of defined compounds isolated from cannabis are now in reach.

Identification of new chemical entities may have slowed down, but natural resources are giving rise to diverse compounds that are poised to make a significant impact on the health and quality of life of many people.

References

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  2. Oberbaum M, and Rosenblum J. A pilot study to evaluate the efficacy of IZN 6D$ for the treatment of diabetic foot ulcers. Journal of Diabetic Complications & Medicine. 2017 Jun;2(1).(Ref.)
  3. Haukioja A. Probiotics and oral health. Eur J Dent. 2010 Jul;4(3):348-355.(Ref.)
  4. Bahl SM. Probiotics in systemic and oral health. Dentistry. 2012 Mar.(Ref.)
  5. Hill KP. Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: a critical review. JAMA. 2015 Jun;313(24):2474-2483.(Ref.)
  6. Lone TL , Lone RA. Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity. Universal Journal of Medicine and Dentistry .2012 April; 1(4): 051-055.(Ref.)
  7. Babayeva M, Assefa H, Basu P,Chumki S, and Loewy Z. Marijuana Compounds: A nonconventional approach to Parkinson’s disease therapy. Parkinson’s Disease. 2016 Dec.(Ref.)