Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati, Delhi, India
Corresponding author details:
Dr. Sehgal VN
Dermato Venerology (Skin/VD) Center Sehgal Nursing Home
Copyright: © 2018 Sehgal VN. This is an openaccess article distributed under the terms of the Creative Commons Attribution 4.0 international License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
To the Editor,
The role of alterations in microanatomy and physiology of stratum corneum, sturdy
skin barrier, has been subject of an intriguing dialogue [1-5] ever since its initial speculation
 in the year 2003. The precise, details of the same have been vividly outlined recently
. A continuing endeavor to find a plausible sequence of events determining the natural
history of atopic dermatitis to be a focus, warranting attention to the role of hyaluronan, a
moisturizing factor of stratum corneum supplied from keratinocytes beneath the stratum
corneum layer regulating its mechanical properties . Hyaluronan / Hyaluronic acid
are well known to exist as a water-sorbed macromolecule in the extra cellular matrix,
the Pharmacokinetic and pharmacodynamic of which form the subject matter of another
article . The pre eminent property of hyaluronidase is unique, and was made use of in
combination with pimecrolimus , a well recognized local immuno modulator in the
management of atopic dermatitis with appreciable outcome . Future studies on the role
of hyaluronan in atopic dermatitis along with the other related factors of stratum corneum,
may add to the understanding of atopic dermatitis and its management in the future.
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