ISSN 2631-6714

The Role of Hyaluronan as a Moisturizing Factor in Atopic Dermatitis

Virendra N Sehgal*

Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati, Delhi, India

CitationCitation COPIED

Sehgal VN. COPD in HIV Infected Patients. Clin dermatiol dermatitis. 2018 Aug;1(1):105

Letter to Editor

To the Editor,

The role of alterations in microanatomy and physiology of stratum corneum, sturdy skin barrier, has been subject of an intriguing dialogue [1-5] ever since its initial speculation [6] in the year 2003. The precise, details of the same have been vividly outlined recently [7]. A continuing endeavor to find a plausible sequence of events determining the natural history of atopic dermatitis to be a focus, warranting attention to the role of hyaluronan, a moisturizing factor of stratum corneum supplied from keratinocytes beneath the stratum corneum layer regulating its mechanical properties [8]. Hyaluronan / Hyaluronic acid are well known to exist as a water-sorbed macromolecule in the extra cellular matrix, the Pharmacokinetic and pharmacodynamic of which form the subject matter of another article [9]. The pre eminent property of hyaluronidase is unique, and was made use of in combination with pimecrolimus [10], a well recognized local immuno modulator in the management of atopic dermatitis with appreciable outcome [11]. Future studies on the role of hyaluronan in atopic dermatitis along with the other related factors of stratum corneum, may add to the understanding of atopic dermatitis and its management in the future.


  1. Sandilands A, Sutherland C, Irvine AD, McLean WH. Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci. 2009; 122: 1285-1294. (Ref)
  2. Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol. 2008; 121: 1337-1343.  (Ref)
  3. Levin J, Friedlander SF, Del Rosso JQ. Atopic Dermatitis and the Stratum Corneum: Part 1: The Role of Filaggrin in the Stratum Corneum Barrier and Atopic Skin. J Clin Aesthet Dermatol. 2013; 6: 16-22.  (Ref)
  4. Levin J, Friedlander SF, Del Rosso JQ. Atopic Dermatitis and the Stratum Corneum: Part 2: Other Structural and Functional Characteristics of the Stratum Corneum Barrier in Atopic Skin. J Clin Aesthet Dermatol. 2013; 6: 49-54.  (Ref)
  5. Levin J, Fallon FS, Del Rosso JQ. Atopic Dermatitis and the Stratum Corneum: Part 3: The Immune System in Atopic Dermatitis. J Clin Aesthet Dermatol. 2013; 6: 37-44.  (Ref)
  6. Bouwstra JA, Honeywell-Nguyen PL, Gooris GS, Ponec M. Structure of the skin barrier and its modulation by vesicular formulations. Prog Lipid Res. 2003; 42: 1-36.  (Ref)
  7. Sehgal VN. The Impact of Microanatomy and Changing Physiology of Stratum Corneum, the Skin Barrier, on Evolution of Atopic Dermatitis. J Dermatitis. 2018; 3: 116.  (Ref)
  8. Sakai S, Yasuda R, Sayo T, Ishikawa O, Inoue S. Hyaluronan exists in the normal stratum corneum. J Invest Dermatol. 2000; 114: 1184-1187.  (Ref)
  9. Fraser JR, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med. 1997; 242: 27-33.  (Ref)
  10. 1Sehgal VN, Pahwa M. Pimecrolimus, yet another intriguing topical immunomodulator. J Dermatolog Treat. 2007;18 :147-150.  (Ref)
  11. Frankel A, Sohn A, Patel RV, Lebwohl M. Bilateral comparison study of pimecrolimus cream 1% and a ceramide-hyaluronic acid emollient foam in the treatment of patients with atopic dermatitis. J Drugs Dermatol. 2011 ; 10: 666-672.  (Ref)