BIOMEDICAL RESEARCH AND REVIEWS

ISSN 2631-3944

Role of the Fecal Microbiote in the Treatment of Pseudomembranose Colitis at Purpose of a Clinical Case

Luis Dulcey1*, Jonathan Pineda1, Héctor Moreno1, Jose Sampayo1, Nohemi Molina3, Magaly Quiñones2, Carlos Zambrano2

1 Residents in Internal Medicine ULA, Venezuela
2 Specialist in Internal Medicine ULA Mérida, Venezuela
3 Student of Medicine ULA,, Venezuela

CitationCitation COPIED

Dulcey L, Pineda J, Moreno H, Sampayo J, Molina N, et al. Role of the Fecal Microbiote in the Treatment of Pseudomembranose Colitis at Purpose of a Clinical Case. Biomed Res Rev. 2020 Feb;3(2):123

Abstract

Introduction: Pseudomembranous colitis is an inflammatory affectation of the mucose of the intestine, characterized by the formation of whitish plaques. It is associated with Clostridium difficult infection; it can be associated with other infections, with other noninfectious pathologies and without known cause. 

Current disease and history: A 34-year-old male with a history of post-traumatic paraplegia who in January 2018 presented with an ulcerative lesion in the dorsal region, so they entered the local hospital where they indicated Meropenem, abdominal distension appeared, associated with generalized pain, absence of stools and vomiting. 

Physical and paraclinical exam: In the cardiopulmonary examination without pulmonary or cardiac alterations, at abdominal level abdominal distension associated with tympanism, absence of intestinal noises, and the rest of the normal physical examination. The hematology shows an important leukocytosis. The rest of the exams were normal. He was taken to the operating room with an exploratory laparo to my which showed no alterations. He is taken to the special care area where his pseudo membranous colitis is suspected, he does not improve initially with antibiotic therapy, and he chooses to perform a colonoscopy study. The findings were consistent with this diagnosis, in the aforementioned case we chose to place stool enemas transplanted for a period of 2 days. 

Discussion and conclusions of the case: Stool transplantation is an emerging little-known therapy; we consider it fundamental to conduct studies in our country because of its importance in the future in the management of pseudomembranous colitis in those cases where there is refractoriness to treatment.

Keywords

Enterocolitis Pseudomembranous; Anti-Bacterial Agents; Clostridium Infections; Fecal Microbiota Transplantation

Introduction

Pseudomembranous colitis (CSM) is an inflammatory affectation of the mucosa of the large intestine, characterized by the formation of characteristic and similar histological and endoscopic whitish plaques: the microscopic and macroscopic image are similar [1,2]. It is a descriptive term that, although characteristically associated with Clostridium Difficile (CD) infection, can be related to other infections, other non-infectious diseases and no known cause. From the opposite point of view, the CSM is but the most characteristic and classic picture, known for more than a century, within the clinical spectrum originated by CD, which includes from asymptomatic carriers to fulminating CSMs passing through very variable diarrheal symptoms clinical significance [3,4] (Table 1).