BIOMEDICAL RESEARCH AND REVIEWS

ISSN 2631-3944

Investigation of Cerebral Aneurysm Disease and Technologies for Treatment

Mojtaba Sadeghian1*, MofidGorji-Bandpy1

1 Department of Mechanical Engineering, Babol Noshirvani University of Technology, Iran (Islamic Republic of)

CitationCitation COPIED

Sadeghian M, Gorji-Bandpy M. Investigation of Cerebral Aneurysm Disease and Technologies for Treatment. 2020 Jan;3(1):115

Abstract

Aneurysms are one of the most catastrophic cerebral emergencies that causes into high mortality. Clinical observations shed the light on aneurysm development which is reported that aneurysm is likely to be related to the hemodynamics condition of the blood vessel in brain. Although the mechanisms of the formation, growth and rupture of aneurysms are not fully discovered but local hemodynamic crucial factors such as dynamic pressure, wall shear stress, blood flow velocity, and residence time are thought to play dominant roles in the growth and initiation of aneurysms, and also the success or failure of aneurysm therapies. Computational Fluid Dynamics (CFD), a numerical simulation aims to provide data, which will help in clinical decision in recognizing the aneurysms at risk of rupture and in the treatment of them.

Keywords

Aneurysm; CFD; Wall Shear Stress; Blood Flow; Stent; Endovascular Embolization; Treatment 

Introduction

Cerebral aneurysms are pathologic dilations of the arterial wall that frequently occurred at or near arterial bifurcations. The exact cause of aneurysm formation remains unclear; but there isevidence that high shear stress and blood velocity may provide the hemodynamic environment fordegenerative vascular injury.

Flow patterns incerebral artery bifurcations and bends have been the subject of comprehensive investigation [1-3]. The growth of cerebral aneurysm may compress brain tissues and surrounding nerves which may cause one or more health conditions; including vomiting, headache, nerve paralysis, seizure and body numbness. When the cerebral aneurysm ruptures generally causes internal bleeding, in the end which in several cases causes death. Stroke is one of the prominent reasons of death in the US. Subarachnoid hemorrhage explains about 7% of stroke cases and most of these cases are caused by rupture of a cerebral aneurysm [4]. Around 50% of patients with aneurysmal will suffer serious disability or die as a result of the initial hemorrhage [5]. The flow dynamics of cerebral aneurysms havebeen studied in numerous experimental models andclinical studies to investigate the role of hemodynamicforces in the initiation, growth, and rupture of cerebral aneurysms (Figure 1).