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We are pleased to make your acquaintance. On behalf of the editors of our esteemed journals it is an honor to invite researchers of every field including Science, Technology, Engineering and Mathematics (STEM) to publish their findings with us. Join hands with Boffin Access on a journey to disseminate your research and expertise to those in need across the globe through Open Access.

Open Access publishing model provides unrestricted access to published content without an embargo period, allows reprint, reuse and distribution of original content. We have so far published works of renowned scientists, young researchers and experts from both academia and industry. Following the Directory of Open Access Journals (DOAJ) guidelines, our journals do not require subscription to access the full text of articles.

Boffin Access Limited is dedicated to publishing extraordinary content while adhering to the high standards of internationally accepted code of publication ethics outlined by COPE. Our committed team of editors and editorial staff take rigorous steps and make independent decisions to ensure content quality. In addition, we put every effort into publicizing our journals among a wide range of scientific and academic communities.

Come and join Boffin Access Limited. in expanding and contributing to the wealth of human knowledge. With our platform we hope to maximize the reach of your unique expertise and skill set to inspire and guide future generations onto a path of creative and sustainable innovation.

Recently Published Articles


Opioid Withdrawal after Sufentanil-induced Anesthesia

This clinical case reports a withdrawal syndrome following intravenous administration of sufentanil to a young woman for short-term anesthesia. Hypotheses are issued and documented. The first, being the fact that the patient had a low liposuction-related fat mass resulting in fast lipid release of sufentanil. The second was a relative overdose of sufentanil leading to non-release of encephalin.

I observed a morphine withdrawal following a gynecological procedure on a small uterine polyp. Anesthesia procedure consisted of: propofol 200 mg, sufentanil 10 mg, droperidol 1.25 g, administered intravenously. The symptoms observed in the 37-year-old woman, 8 hours after surgery, were: derealization, hyperthermia, paresthesia and myoclonus of the upper and lower limbs, gastric embarrassment[1].

The duration of the symptoms for about 3 hours was more representative of a morphine withdrawal; if some symptoms are closed to a panic attack the duration is different. In case of a panic attack the cessation of symptomatology is around 20 minutes.

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Doppler-Guided Haemorrhoidal Artery Ligation (HAL) and its Effectiveness in Achieving Patient Satisfaction in Haemorrhoidal Bleeding

Background: Doppler-guided Haemorrhoid Artery Ligation (HAL) of the terminal branches of the superior haemorrhoidal artery is an increasingly popular technique in haemorrhoid management.

Objectives: The aim was to assess the role of Doppler HAL in haemorrhoid management, patient outcomes and satisfaction.

Materials and Methods: The study was a prospective case series, analysed retrospectively. Seventy-eight consecutive patients undergoing Doppler HAL for Grade III and IV haemorrhoids at a single metropolitan private hospital in Sydney, Australia were included in the study. A modified proctoscope housing a Doppler transducer was used to sequentially suture ligate the haemorrhoidal arteries. The authors report our preliminary experience with regards to post-operative symptoms, re-intervention requirements and overall patient satisfaction with the procedure and symptom management.

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Synaptic-Adhesion Molecules Neurexin 1 and Neuroligin 1 as Novel Prognostic Factors in Oral Squamous Cell Carcinoma

Background: Synaptic adhesion molecules regulate synapse development and maintenance. Neurexins and neuroligins have been implicated in psychiatric disorders, and shown that they are related to vascular system and carcinomas in recent studies. In the present study we focused neurexin 1 and neuroligin1, and investigated the relationship between those two molecules expression and clinical features of oral cancer.

Materials and methods: Fifty-six biopsy samples from oral squamous cell carcinomas (OSCCs) were analyzed semi quantitatively by immunohistochemistry. Correlations between the expression level of neurexin 1, neuroligin 1, p53, Ki67 and the clinical features of OSCCs were statistically analyzed.

Corresponding author: Toru Yanagawa, D.D.S., M.D., Ph.D., Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, sukuba-shi, Ibaraki-ken, Japan, Phone/fax: 81-29-853-3192, E-mail: ytony@md.tsukuba.ac.jp

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Ultraviolet Laser Ablation of Trabecular Meshwork and Limbus in Rats

Background/Aims: The purpose of this study was to determine the ability of intraocularly delivered 213 nm UV laser pulses to ablate the trabecular meshwork and to monitor the healing process in an in vivo rat model. The long-term aim is to develop a new form of glaucoma surgery to cut a permanent drainage channel through the trabecular meshwork.

Methods: The rat was anaesthetized and its head securely mounted in a stereotaxic device. The eye was stabilized by suturing to an eye ring held in the stereotaxic frame. The fiberoptic delivery probe entered the eye through a freshly ablated channel through the cornea and passed across the anterior chamber under gonioscopic observation, to touch the trabecular meshwork on the nasal side. Laser lesions were then induced using either 100 pulses at a fluence of 0.4 J.cm-2 or 50 pulses at 0.6 J.cm-2. The rat eye was enucleated either immediately at the end of the laser treatment, or after a two week recovery period, and processed for histology.

Corresponding author: Dao-Yi Yu, Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, Australia, E-mail: dyyu@lei.org.au

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Discourse Analysis of Multilingual In-door Advertisements of Dili, Timor Leste

This article presents a study on multilingual in-door advertisements in Dili Timor Leste (TL). The multilingual in-door advertisements were collected by photographing them for the data. They were also collected from written documents and internet. The data were in language but in syllables of advertisements. The 402 multilingual syllables were used as data samples. It was found that most of the advertisements obtained used words of four different languages: Tetun, Portuguese, English, and Indonesian in advertisements. By applying discourse analysis model of Norman Fairclough to analyse the data, the study reports the following results: (1) Most of the multilingual in-door advertisements have completed the instruction of TL constitution that Tetun is used as national language; (2) Most of the advertisement texts produced, distributed and consumed are regarded as segements of four languages mentioned above; (3) The advertisement text messages show socio-cultural meanings regarded as text backgrounds. The theoretical implication of the study is that, the discourse analysis model of Norman Fairclough is not so precise to analyse texts without certain contexts. However, this research contributes much to TL government to design a regulation or other guides for processing bussiness advertisements in TL.

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Open Reading Frame Filtering Methods for Identification of Genic Sequences

Tumor necrosis factor alpha (TNF-α) is known to cause selective destruction of tumor neovascularisation. Perfusion changes in tumor microenvironment were studied in a young patient with a high-grade myxoid liposarcoma after isolated limb perfusion with TNF-α and melphalan, using advanced MR imaging. Quantitative and semi-quantitative evaluation of perfusion metrics included ktrans/f/T2* shift and automatic extraction of enhancement patterns. Strong agreement between different methods is consistent with response to therapy, specifically reduced perfusion (mean ktrans shifted from 0.424 to 0.099 mL/g/min, mean f from 33.5 to 7.3%), reduced hypoxia indication (mean T2* increased from 72 to 82 ms) and prevalence of necrotic areas.

Corresponding author: Katerina Nikiforaki, CBML, Foundation for Research & Technology, N.Plastira 100, Vasilika Vouton 70013, Heraklion, Crete, Greece, Tel: +30 2810391658, E-mail: nikiforakik@gmail.com

Citation: Nikiforaki K, Manikis GC, Venianaki M, Lagoudaki E, Maris TG, et al. Perfusion and oxygenation changes after isolated limb perfusion with TNF-α in lower limb sarcoma: a case report. Biomed Res Rev. 2018Mar; 1(1):101.

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Acute Hyponatremia Induced by Bowel Preparations for Colonoscopy: Identification of Patients at Risk

Introduction: Iatrogenic acute hyponatremia has been observed following bowel preparation for colonoscopy and is believed to be associated with hypo-osmotic preparations.

Aim: To review cases of hyponatremia attributed to bowel preparations for colonoscopy reported to the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).

Methods: All adverse event (ADR) reports to the FAERS reported between March 2008 and May 2014 were reviewed. The data was filtered to cases using the term “colonoscopy” with primary ADRs of “hyponatremia” and/or seizure”. Bowel preparations reviewed (including alternative spellings of brand names) included: OsmoPrep™, MoviPrep™, SuPrep™, Visicol™, Magnesium citrate, Golytely™, MiraLAX™, Trilyte™, Gavilyte™, and Colyte™. Complete reports of all cases were obtained from the FDA using the Freedom of Information Act (FOIA).

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Treatment of Advanced Cancer-related Lymphocytopenia: Comparison among the Effects of Subcutaneous Low-dose Interleukin-2, High-dose Pineal Hormone Melatonin and Checkpoint Inhibitors

Background: Despite the negative prognostic significance of lymphocytopenia is known for many years no clinical cancer study has been proposed up to now in an attempt to specifically correct the evidence of an abnormally low lymphocyte count. At present it is known that IL-2 is the main growth factor for T lymphocytes. Lymphocyte proliferation is also stimulated by the pineal indole hormone melatonin (MLT), which is provided by an anticancer activity, whereas it is inhibited by cortisol.

Objective: On this basis a preliminary study was carried out to evaluate which may be the optimal therapeutic schedule of cancer- related lymphocytopenia.

Methods: The study included 40 advanced solid tumor patients who were treated by the best supportive care (BSC) (n=9), high-dose MLT alone (n=12) at 100 mg/day in the night, subcutaneous low-dose IL-2 alone (n=9) at 1.8 MIU/day for 5 days/week for 2 weeks followed by 2 weeks-rest period, or IL-2 plus MLT. The duration of study was 6 weeks.

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Preliminary Results of Oxygen-ozone Therapy as Support and Palliative Therapy in Cancer Patients with Fatigue

All cancer treatments may cause fatigue and it is hypothesized that the cause is tissue damage, or the accumulation of products derived from dead cells.

From February 2016 to December 2017 we have studied 36 patients with cancer and fatigue (10 with breast cancer, 7 with lung cancer, 7 with colon cancer, 5 with renal cancer, 3 with prostate cancer, 2 with melanoma and 2 hepatocellular carcinoma). Of the 36 patients treated, 10 were during neoplastic treatment, 10 had already finished the cancer therapy and 16 were in a palliative setting. To assess the extent of fatigue in patients we used the Fatigue Severity Scale, which is used to estimate the severity of the symptom with a score from 1 to 7. Patients were treated with auto hemo transfusion (GAE) according to the SIOOT (Scientific Society of Oxygen Ozone Therapy) protocols, twice a week for one month and twice a month as maintenance therapy. No side effects have been found, and 26 patients (72%) achieved a significant improvement (>50% of the symptoms).

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Improved Vaccine Design and Delivery as Part of an Integrated Approach to Meet the Public Health Challenge of Typhoid Fever in Developing Countries

Salmonella enterica serovar Typhi (S. typhi) is a significant cause of typhoid fever in humans. Gastrointestinal infections with this and the closely related bacterium S. paratyphi that causes paratyphoid fever pose a public health challenge, particularly in developing countries where people of all age groups are commonly affected. However, limited data exist to estimate the total clinical burden of such enteric fever in Asian and African countries. Despite the demonstrated success of a number of typhoid vaccines, these are still not deployed widely enough to protect whole communities. In typhoid fever-endemic areas especially there is a pressing need to consider the introduction into routine public health programs of new generation typhoid vaccines. To this end, several novel conjugate vaccines have undergone clinical trials for human use. The optimum age at which children are immunized needs to be re-evaluated as there is a requirement for an efficacious and potent vaccine that can be used in children below the current vaccination window of two to five years of age. This review highlights the key virulence factors of S. typhi that are associated with antibiotic resistance and considers the need to introduce widespread public vaccination programs to help combat typhoid fever worldwide. Improvement in sanitation and water systems is the principal long-term solution to disease prevention.

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About Boffin Access Limited

Boffin access limited is an emerging Open Access publisher with nearly forty journals spanning several fields of Science, Technology, Engineering and Mathematics (STEM). Our aim is to create an international venue for researchers from all walks of life to share and exchange their findings in order to push the boundaries of current knowledge.

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EDITOR IN CHIEF'S
Invocation to
Scientific Publications

Forthcoming Special Issues

Journal Name: Journal of Cancer Research and Oncobiology (ISSN 2517-7370)
Title: Clinical Translational Research In Breast Cancer
Editor: John Yahya I Elshimali...Read more

Journal Name: Methods of Microbiology and Molecular Biology (ISSN 2517-7435)
Title: CRISPR, Genome Editing and Promotion in Plant Science
Editor: Ali Movahedi...Read more

Journal Name: Journal of Neuroscience and Neurosurgery (ISSN 2517-7400)
Title: Neurobiology of Anxiety and Mood Disorders.
Editor: Michel Bourin...Read more

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